Dr. Osakwe has been active in Tuberculosis control in Nigeria in the past 26 years. His career in TB control started during his National Youth Service Corp (NYSC) in 1990 at the Tuberculosis and Leprosy Referral Hospital, Ossiomo, Edo State. After his NYSC, he worked as a Medical Officer for Tuberculosis and Leprosy control at Mile Four Hospital for 10 years. During this time, he contributed to the curing of thousands of persons afflicted with TB and Leprosy. From 2003 to 2005, Dr. Osakwe worked as a Medical Adviser with the German Leprosy and TB Relief Association (GLRA). While at GLRA, he assisted immensely in consolidating the TB and Leprosy Control programmes in the South East, South South and South West zones of the country. At GLRA, he was at the forefront of establishing collaboration between the government TB programme and private health care practitioners in TB control.

Dr. Osakwe worked as a National Professional Officer (NPO) with the World Health Organization (WHO) from 2005 to 2016. During this period, he contributed in the development of numerous policies and guidelines for the control of TB in Nigeria as well as conducting supervision, monitoring and evaluation for the TB control programme. He was one of the zonal team leaders in the first nationwide TB prevalence survey that was conducted in the country in 2012. Dr. Osakwe is a training facilitator for the national TB control programme and other TB control partners has facilitated in numerous training TB control training workshops in the country. In addition to running the affairs of the NGO, he also consults for the national TB control programme and many other organisations involved in TB control in Nigeria.